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WHAT CAUSES CERVICAL CANCER?"Virtually every cancer cell has an abnormal chromosome component, whereas virtually every normal cell has the normal diploid number."
- Dr. Bert Vogelstein, Johns Hopkins University
An HPV infection is a necessary but not sufficient condition for the development of cervical cancer. In fact, 90% of HPV infections regress within 2 years1. This holds true in clinical practice as only a small number of infected patients progress to severe dysplasia.
DNA damage to chromosomal biomarkers 3q26 and 5p15 in HPV-infected cervical and dysplastic cells may be more predictive of the progression to disease 2-6.
The Cervical DNA Dtex Test identifies the irreversible DNA damage* to cervical cells.
References:
1 - Dunne et al., JAMA, 2007
2 - 2010 SGO Annual Meeting on Women’s Cancer
3 - Heselmeyer et al., American Journal of Pathology, 1996
4 - Heselmeyer et al., Genes, Chromosomes, & Cancer, 1997
5 - Heselmeyer-Haddad et al., American Journal of Pathology, 2005
6 - Andersson et al., American Journal of Pathology, 2009
* as defined by multiple copies of 3q26 and/or 5p15 in cervical cells
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